The Effectiveness of Sea Urchin Extract (Echinometra matthaei) for Wound Healing on Deep Second-Degree in White Rats (Rattus norvegicus) Wistar

Background: Burns is a form of tissue damage caused by high temperatures. Echinometra matthaei sea urchins have several secondary metabolites that can potentially help in the healing process burns. In this study, 70% E. ethanol extract was formulated O / W (oil water) type cream preparations which were applied topically. Objective: This study aims to determine effectiveness on second-degree burns Wistar strain rats. made 3 formulations, namely Formulation 1 (extract concentration 1%), 2 3%), and 5%). research conducted for 7 days with method used post-test only control group design. Experiments given induction using hot plate diameter 20 mm at temperature ± 200ºC 15 seconds. Wound observed periodically observing macroscopically inflammation inflammatory phase growth proliferation phase. Results: The average percentage showed improvement F2: 100%, F1: 80%, F3: 71% results better than wound group: 50% as evidenced value α = 0.012 (